Over long periods (read: many, many years) of time, yes. Effect: High end reproduction levels are reduced. This time frame is escalated when used in heavy dust or smokey environments with lack of maintenance.
If your dots are that hard to see good for you!! Just keep vacuuming and it will help delay the mighty onslaught of the dreaded DOTS!!!
But with frequent maintenance (vacuum) this helps with the build-up. Just unplug them before going to bed, and vacuum them the next morning, then plug them back in. I start out with my drapery brush, then use my crevase tool on my sweeper. Works very well. Someone made a great post here that if you see dust on the edges of the cabinets (top of panels/cabinet), it is time to vacuum them.
Also another user here acutally spent a few hours on each panel cleaning the dots with some Q-Tip devices and removed most of the dot. They are the first to claim this type of cleaning method. It can be found in the threads here with a search.
I vacuum mine once a month no matter what.
Dan