Much like many other aspects of this hobby, I've found that there is no real "magic bullet" when it comes to isolation. The only real exception is the "mass damping" thing--heavy platforms under components (and in some case, heavy, dense things places ON components) can make a BIG difference, especially if your listening room in on a sprung-wood floor.
Different things work better for different applications.
My speakers are ALL sitting on 1.5" OreveonDV spikes. They made a big improvement over the stock old-style POS spikes that ML used to ship with their speakers.
I've got all my components on some sort of stone-like slabs. My TT sits on a 24" x 24" x 1" slab of slate flagstone, which is perched on top of 5 rubber balls (practice lacrosse balls to be exact), which sit on a double-thick shelf in my modified Ikea rack. (The rack has spikes feet, and all the steel-tube supports have been filled with lead shot).
My monoblocks sit on 10" x 24" x2" cast concrete pavers. The pavers are perched on 1.75" OregonDV spikes. The amps sit on the pavers atop Ceramic Isopod cones (they were made in Canada back in the 1990's, but the company is no longer around..).
All my other "active" components sit atop Travertine marble tile, with different cones or feet.
My Krell preamp also sits on Isopods, the Oppo sits on a set of Russel Andrews ceramic cones, the Benchmark sits on a set of 1.75" sorbothane-topped "AV Rizer" footers. The Carver C-400t sits atop a vintage set of ModSquad silver aluminum TipToes with matching TipToe "shoes".
When I hook my laptop to the 2-channel rig, It sits on a marble slab, atop 4 PWX Postballs (I use 2 Postballs in the rear of the laptop when I'm actually working on it, for air circulation).
My speaker cables and ICs between the pre and amps are all run atop big ceramic telegraph insulators (the "original" cable lifters!).
Almost everything I've tried over the years with regards to isolation has had SOME sort of effect. Some things were VERY noticeable (the Isopods were the most audible difference of any footer I've used), some were VERY subtle (the Russ Andrews cones), some made things noticeably tighter (the OregonDV spikes) and some things actually made things sound worse (AudioQuest and Moster Sorbothane footers I used back in the day, in different configurations, under CD players, Preamps, Turntables--no matter what I put those footers under, it seems to make the bass sound loose, and the soundstage was noticeably smeared). Those big ceramic Isopod cones seem to work best under HEAVY components like amps and that Krell preamp, but not so much under lighter components like CD players, DACs, etc. (although they DID work well under the Meridian 208 I used to have, but then again that CD player was something like 28lbs...)
Not EVERY isolation tweek I've tried worked for the better, but they all have made SOME difference. The current setup that my TT sits on went through about 5 different iterations before I got it all sussed out, and dialed in, using different "hardnesses" for the balls (tennis balls, handballs, hard lacrosse balls, Ceramic balls, and finally "medium" lacrosse balls. In between various balls, I tried bicycle inner tubes, bean bags, sand bags and even those squishy liquid-filled "cold packs" (but at room-temperature of course). It was THAT ongoing experiment of about 3 years of tweeking that finally convinced me that EVERYTHING makes SOME difference in this hobby--not always good, mind you, but just about ANYthing you do when it comes to your setup will have some sonic effect.
And it's not just isolation that makes a difference--cabel routing can make things sound better or worse. Power conditioning is a BIG one. Even location in the room relative to the speakers can make a noticeable difference with some components (particularly TT's). Heck, I'm even convinced that the order in which you power up your components can actually effect the way a system ultimately sounds during any given listening session...
But of course, YMMV. In a quantum world, they tell us that the observer DOES effect the outcome of any given event, and I believe that works on the macro as well as the sub-atomic level. So if you are a skeptic, the same things might not make as much of an improvement for you as they do for someone who is a "true believer". After all, the entire universe is essentially just concentrated clusters of vibrating energy packets, and how those clusters resonate with each other is what "reality" is all about. To deny that quantum effects are real on the macro level is simply living in denial of the fundamental nature of "being"...
In other words, if you want to make an improvement in your system, the first step is to WANT to hear an improvement...